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Th17 Cells - A New T Cell Lineage
یکشنبه 24 دیماه سال 1391 16:36
CD4+ T helper cells are critical mediators of the cellular immune response. For many years, due to cytokine expression patterns, it was thought that CD4+ T helper cells existed as a dichotomy of lineages named Th1 and Th2. However, as these subsets were analyzed more closely, it became apparent that the T helper cell...
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Immunotherapy in prostate cancer: Emerging strategies against a
یکشنبه 24 دیماه سال 1391 16:32
Recent clinical trials have shown therapeutic vaccines to be promising treatment modalities against prostate cancer. Unlike preventive vaccines that teach the immune system to fight off specific microorganisms, therapeutic vaccines stimulate the immune system to recognize and attack certain cancer-associated proteins....
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Il-6 signaling in inflammatory bowel disease
یکشنبه 24 دیماه سال 1391 13:10
Abstract Crohn's disease (CD) and ulcerative colitis (UC) are chronic inflammatory bowel diseases (IBDs) occurring in the gut of genetically susceptible individuals independent of a specific pathogen. The interaction between antigen-presenting cells and the local bacterial flora contributes to an uncontrolled...
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.:: آسپرین و افزایش طول عمر مبتلایان به سرطان پروستات ::.
یکشنبه 24 دیماه سال 1391 04:39
مطالعات اخیر نشان میدهند که مردان مبتلا به سرطان پروستات که تحت درمان های رایج از جمله جراحی و پرتودرمانی قرار گرفته اند، میتوانند با مصرف منظم آسپرین، طول عمر بیشتری داشته باشند. بر اساس تحقیقات، آسپرین و سایر داروهای ضد انعقاد مانند وارفارین، کلوپیدوگرل و انوکساپارین، رشد و گسترش سلول های سرطانی را به ویژه در نوع پر...
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Major Histocompatibility Complex - MHC
شنبه 23 دیماه سال 1391 18:44
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A critical review of the role of the MHC in ...
شنبه 23 دیماه سال 1391 18:39
A critical review of the role of the major histocompatibility complex in fertilization, preimplantation development and feto-maternal interactions. From conception to old age, the major histocompatibility complex (MHC) is at the centre of immune responses that aid survival, fitness and adaptation of mammalian species...
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Sphingosine 1-phosphate and its type1 G protein-coupled receptor
شنبه 23 دیماه سال 1391 18:34
Sphingosine 1-phosphate and its type 1 G protein-coupled receptor: trophic support and functional regulation of T lymphocytes. The lysophospholipid (LPL) growth factors sphingosine 1-phosphate (S1P) and lysophosphatidic acid (LPA) are generated by macrophages, dendritic cells, mast cells, and platelets, which leads to...
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Cellular and molecular basis for the regulation of inflammation
پنجشنبه 21 دیماه سال 1391 21:57
Cellular and molecular basis for the regulation of inflammation by TGF-β Transforming growth factor-β (TGF-β) has been shown to play an essential role in the suppression of inflammation, yet recent studies have revealed the positive roles of TGF-β in inflammatory responses. For example, TGF-β induces Foxp3-positive...
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IgE-mediated food allergies in Swiss infants and children
پنجشنبه 21 دیماه سال 1391 21:55
OBJECTIVE: To determine the most frequent food allergens causing immediate hypersensitivity reactions in Swiss children of different age groups and to investigate the clinical manifestation of IgE-mediated food allergies in young patients. PATIENTS AND METHODS: The study was a prospective analysis of children referred...
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Obesity is associated with macrophage accumulation in adipose ti
سهشنبه 5 دیماه سال 1391 17:02
Obesity alt ers adipose tissue metabolic and endocrine function and leads to an increasedrelease of fatty acids, hormones, and proinflammatory molecules that contribute to obesity associated complications. To further characterize the changes that occur in adipose tissue with increasing adiposity, we profiled...
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Th17 and Regulatory T cells in Women with Recurrent Pregnancy Lo
سهشنبه 5 دیماه سال 1391 16:54
The immune system of pregnant women is tightly controlled to defend against microbial infections and at the same time, to accept an embryo or the fetus, which are expressing semi-allogenic paternal antigens. Furthermore, inflammation-like processes are crucial for tissue growth, remodeling, and differentiation of the...
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مقایسه سطح سرمى اینترلوکین هشت در بیماران مبتلا به آفت عود کننده
شنبه 25 آذرماه سال 1391 14:52
ضایعات آفتى عود کننده شایعترین زخمهاى مخاط دهان میباشد و با توجه به روند التهابى این ضایعات، سایتوکاینهاى پیش التهابى از جمله اینترلوکین هشت (IL8) میتواند افزایش یابد. هدف از این مطالعه بررسی این سایتوکاین التهابی در بیماران مبتلا به آفت با افراد سالم میباشد. روش بررسی: در این مطالعه تحلیلى، دو گروه شامل چهل بیمار...
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Cytokine Mediators of Immunity and Inflammation
دوشنبه 20 آذرماه سال 1391 09:17
served the cause of surgical science well. Our understanding of basic disease mechanisms and insights into potential new therapeutic strategies have occurred at a staggering pace. Perhaps nowhere in surgical biology are these mechanistic insights and therapeutic prospects more evident than in research defining the...
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Soluble human complement receptor type 1
دوشنبه 20 آذرماه سال 1391 09:14
The complement system is an important mediator of the acute inflammatory response , and an effective inhibitor would suppress tissue damage in many autoimmune and inflammatory diseases . Such an inhibitor might be found among the endogenous regulatory proteins of complement that block the enzymes that activate C3 and...
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[ بدون عنوان ]
دوشنبه 13 آذرماه سال 1391 08:09
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Macrophage activation syndrome
دوشنبه 6 آذرماه سال 1391 10:27
Macrophage-activation syndrome (MAS) is a severe, potentially life-threatening, complication of several chronic rheumatic diseases of childhood. It occurs most commonly with systemic-onset juvenile idiopathic arthritis (SoJIA), which is also known as Still's disease . In addition, MAS has been described in association...
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Immunomodulatory Effects of Astragalus gypsicolus Hydroalcoholic
دوشنبه 6 آذرماه سال 1391 09:57
Several studies have demonstrated that herbal extracts possess various biological effects including anti-inflammatory and anti-cancer activities. The present study was aimed to investigate the protective effects of the early allergic sensitized mice induced by ovalbumin. Phytochemical assay was used to recognize the...
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Metabolite profiles of human immunodeficiency virus infected CD4
دوشنبه 29 آبانماه سال 1391 09:36
Abstract Human immunodeficiency virus type 1 (HIV-1) infects both activated CD4+ T cells and macrophages. We tested if liquid chromatography–tandem mass spectrometry (LC–MS/MS) technology can monitor metabolic alterations induced by HIV-1 in the infected cells. Here we monitored glucose uptake and conducted...
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[ بدون عنوان ]
دوشنبه 29 آبانماه سال 1391 09:31
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[ بدون عنوان ]
دوشنبه 29 آبانماه سال 1391 09:24